The Garvan Institute of Medical Research is one of Australia's leading medical research institutes, with over 600 scientists, students and support staff. We pioneer study into the most widespread diseases affecting our community today, including cancer, neurodegenerative and mental diseases, disorders of the immune system, diabetes and obesity, osteoporosis and other skeletal disorders. The Ovarian Cancer Research Laboratory at the Garvan Institute has a particular interest in the application of genomic technologies to address clinically significant issues such as primary and acquired chemoresistance. The lab spans the Garvan Institute and the Peter MacCallum Cancer Centre (Melbourne) through Professor David Bowtell's joint appointment at these two leading institutions. Garvan Institute of Medical Research The Bioinformatics Research Officer will focus on the implementation, development and support of computational and statistical tools for the analysis and interpretation of next-generation sequencing (NGS) data. Specifically, the Bioinformatics Research Officer will assist and provide insights into the genomic analysis of primary and acquired chemoresistance in ovarian cancer. In addition to providing support for the existing team, the Bioinformatics Research Officer will have the opportunity to develop their own research interests, as we expand on our previous work describing whole genome sequencing (WGS) of chemoresistant ovarian cancer (Patch et al. 2015 Nature). Responsibilities will include: Establish and optimise a bioinformatics pipeline for the analysis of NGS data
Variant verification and expression analysis using transcriptome data
Analysis of SNP array data to determine copy number and explore phylogenetic relationships between tumour samples
Integrative analyses combining WGS, copy number, methylation and expression data
Statistical analyses, such as associating molecular features with clinical outcomes
Keeping abreast of advances in genomic technologies and informatics tools
Qualifications, skills and experience required: PhD in Bioinformatics or equivalent experience in a related field
Excellent computational background, especially in the management of large data sets in unix/linux environment
High proficiency in programming and scripting languages (e.g. C/C++, Java, Perl, Python)
Advanced user of the R programming language and R-based statistical packages and tools, such as those available from the Bioconductor project for high throughput genomic data analysis
Good knowledge of statistics and presentation of molecular/clinical data
Experience in the analysis and interpretation of large genomic data sets (WGS, RNAseq)
A proven track record, e.g. publications, grants, software/tool development
The Offer Garvan offers a friendly and professional work environment in state of the art modern building and facilities, on-site café, social club and close to cafes and public transport. You'll be rewarded with a competitive salary, above market Superannuation and attractive salary packaging options. This role is Full-time for an initial 2 year fixed term contract.
How to apply Please prepare your application and submit via the directions below: Cover Letter addressing the Selection Criteria above Your CV including 3 Referees This role will remain open until filled. We are reviewing applications as we receive them.
Apply OnlineThe Bioinformatics Research Officer will focus on the implementation, development and support of computational and statistical tools for the analysis and interpretation of next-generation sequencing (NGS) data. Specifically, the Bioinformatics Research Officer will assist and provide insights into the genomic analysis of primary and acquired chemoresistance in ovarian cancer.
#J-18808-Ljbffr
